Growth Hormone Therapy in Children with Chronic Renal Failure

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Growth hormone therapy in children with chronic renal failure.

Growth is impaired in a chronic renal failure. Anemia, acidosis, reduced intake of calories and protein, decreased synthesis of vitamin D and increased parathyroid hormone levels, hyperphosphatemia, renal osteodystrophy and changes in growth hormone-insulin-like growth factor and the gonadotropin-gonadal axis are implicated in this study. Growth is adversely affected by immunosuppressives and c...

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Comparison of Growth Parameters in Two Groups of Children with Chronic Renal Failure Treated with and without Growth Hormone Replacement Therapy

Objective: The aim of the present study was to evaluate the effect of growth hormone on growth parameters such as Z scores for height, weight, and body mass index (BMI), and height velocity in two groups of children with chronic renal failure (CRF) treated with and without growth hormone.Methods: This longitudinal study was conducted on all children aged 6 months to 16 years with a short ...

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Growth hormone therapy in calcium-loaded rats with renal failure.

GH increases linear growth in children with chronic renal failure, but the response remains suboptimal in some patients. Some of the factors that may explain the poor response to GH include high doses of calcitriol and exogenous calcium loading to prevent hyperphosphatemia. High doses of exogenous calcium adversely affect chondrocyte proliferation and delay mineralization in the growth plate of...

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Etiology of Chronic Renal Failure in Children and Lnfants

Chronic renal failure is an uncommon disease in children with some difference in the etiology in different countries. In this study on 180 children (From 1987 to 1997 in Shiraz) with age range of 3 months to 15 years (mean 8.6±4.2 years). The male to female ratio was 1. 57: 1. The etiology of chronic renal failure in decreasing order of frequency were: reflux nephropathy (25 % ) , glbmerular di...

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Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone.

OBJECTIVES We aimed to determine whether growth hormone (GH) resistance is present in patients with chronic heart failure (CHF) and whether it may be linked to the biochemical response to GH treatment. BACKGROUND Acquired GH resistance is a feature of severe illness, in particular, cachexia. In patients with CHF, the response to GH therapy appears to be variable. METHODS Biochemical markers...

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ژورنال

عنوان ژورنال: The Eurasian Journal of Medicine

سال: 2015

ISSN: 1308-8734,1308-8742

DOI: 10.5152/eajm.2014.57